Saos-2 cells
Saos-2 cells
Saos-2 cells (pronunciation: /sɑːs tuː sɛlz/) are a type of cancer cell line that is commonly used in biological research. They were originally derived from a primary osteosarcoma, a type of bone cancer, in an 11-year-old girl.
Etymology
The name "Saos-2" is an acronym for "Sarcoma osteogenic", which refers to the type of cancer from which the cells were derived. The "2" indicates that this is the second cell line derived from this particular patient.
Characteristics
Saos-2 cells are known for their high level of alkaline phosphatase activity, a characteristic of osteoblasts, the cells that form new bone. They also express high levels of Type I Collagen, another marker of osteoblast activity. These characteristics make Saos-2 cells a useful model for studying bone formation and osteoblast biology.
Use in Research
Saos-2 cells are used in a wide range of research applications. They are often used to study the biology of osteosarcoma and to test new treatments for this disease. They are also used in studies of bone formation and osteoblast biology, as well as in research on cellular aging and cancer biology.
Related Terms
- Osteosarcoma: A type of bone cancer from which Saos-2 cells were derived.
- Osteoblast: The type of cell that forms new bone, and which Saos-2 cells resemble in many ways.
- Alkaline phosphatase: An enzyme that is highly active in Saos-2 cells and is a marker of osteoblast activity.
- Type I Collagen: A protein that is highly expressed in Saos-2 cells and is a marker of osteoblast activity.
External links
- Medical encyclopedia article on Saos-2 cells
- Wikipedia's article - Saos-2 cells
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