SRX251

A selective vasopressin V1A receptor antagonist

SRX251 is a chemical compound that acts as a selective antagonist of the vasopressin V1A receptor. It is primarily used in scientific research to study the role of vasopressin in various physiological and behavioral processes.

Chemical Properties

Chemical structure of SRX251

SRX251 is a small molecule with a specific affinity for the vasopressin V1A receptor. The chemical structure of SRX251 allows it to bind selectively to this receptor subtype, inhibiting its activity. This selectivity is crucial for research applications, as it enables scientists to isolate the effects of V1A receptor antagonism without affecting other vasopressin receptors.

Mechanism of Action

SRX251 functions by blocking the action of vasopressin at the V1A receptor. Vasopressin, also known as antidiuretic hormone (ADH), is a peptide hormone that plays a key role in regulating water retention in the body, blood pressure, and social behaviors. By antagonizing the V1A receptor, SRX251 can modulate these physiological processes, making it a valuable tool for studying the specific contributions of V1A receptor signaling.

Research Applications

SRX251 is used extensively in preclinical research to explore the role of vasopressin in various conditions. Some of the key areas of research include:

Social Behavior

Vasopressin is known to influence social behaviors, including aggression, pair bonding, and social recognition. Studies using SRX251 have helped elucidate the specific contributions of the V1A receptor in these behaviors. For example, SRX251 has been used to investigate the role of vasopressin in aggression and social memory in animal models.

Stress and Anxiety

The V1A receptor is also implicated in the body's response to stress and anxiety. By using SRX251, researchers can study how blocking this receptor affects stress-related behaviors and physiological responses. This research has potential implications for developing new treatments for anxiety disorders.

Cardiovascular Function

Vasopressin plays a role in regulating blood pressure and cardiovascular function. SRX251 is used to study the effects of V1A receptor antagonism on cardiovascular parameters, providing insights into potential therapeutic applications for hypertension and other cardiovascular conditions.

Potential Therapeutic Uses

While SRX251 is primarily a research tool, its ability to selectively block the V1A receptor suggests potential therapeutic applications. For instance, it could be explored as a treatment for conditions where vasopressin signaling is dysregulated, such as certain anxiety disorders or cardiovascular diseases. However, further research and clinical trials would be necessary to evaluate its safety and efficacy in humans.

Related Pages

• Vasopressin
• Vasopressin receptor
• Antidiuretic hormone
• Receptor antagonist