SOD1
SOD1 or Superoxide Dismutase 1 is an enzyme that in humans is encoded by the SOD1 gene. It is one of three human superoxide dismutases. It is implicated in amyotrophic lateral sclerosis (ALS), a neurodegenerative disease that affects nerve cells in the brain and spinal cord.
Function[edit]
SOD1 is a soluble cytoplasmic and mitochondrial intermembrane space protein. It binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a homodimer and is thought to protect cells from superoxide damage, while its dysfunction is associated with several diseases.
Clinical Significance[edit]
Mutations in the SOD1 gene are associated with familial amyotrophic lateral sclerosis (ALS). Research has suggested that the mutations cause a toxic gain of function, rather than loss of enzymatic activity. This is thought to be a major driver of the pathology of ALS.
See Also[edit]
References[edit]
<references />
External Links[edit]
- SOD1 on WikiMD
 | This medical article is a stub. You can help WikiMD by expanding the page. |
Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
