SLC2A12

SLC2A12 is a gene that encodes a protein known as solute carrier family 2 member 12, also known as GLUT12. This protein is a member of the solute carrier family, which are integral membrane proteins that facilitate the transport of many different solutes across biological membranes.

Function

The SLC2A12 gene is responsible for the production of the GLUT12 protein. This protein is involved in the transport of glucose and other hexose sugars across the cell membrane. It is primarily expressed in insulin-sensitive tissues such as adipose tissue, skeletal muscle, and the heart. The exact role of GLUT12 in glucose transport and metabolism is still under investigation, but it is thought to play a role in insulin resistance and diabetes.

Clinical significance

Mutations in the SLC2A12 gene have been associated with various health conditions. For example, a study found that a variant of the SLC2A12 gene was associated with an increased risk of type 2 diabetes. Another study found that the SLC2A12 gene was overexpressed in breast cancer cells, suggesting that it may play a role in cancer development or progression.

Research

Research into the SLC2A12 gene and the GLUT12 protein is ongoing. Understanding the role of this gene and protein in glucose transport and metabolism could lead to new treatments for conditions such as diabetes and cancer.

See also

• Solute carrier family
• Glucose transporter
• Insulin resistance
• Diabetes
• Breast cancer

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