SLC22A7

SLC22A7 is a gene that encodes a protein in the human body. This protein is part of the solute carrier family 22, which is a group of proteins that help transport various substances across the cell's membrane. The SLC22A7 protein is also known as the organic anion transporter 2 (OAT2).

Function

The protein encoded by the SLC22A7 gene is involved in the transport of organic anions. These are negatively charged molecules that include a wide range of substances, such as hormones, drugs, and metabolic waste products. The SLC22A7 protein is primarily found in the liver and kidney, where it plays a crucial role in the elimination of these substances from the body.

Clinical Significance

Mutations in the SLC22A7 gene can lead to a variety of health problems. For example, they can cause a decrease in the body's ability to eliminate certain drugs, leading to drug toxicity. They can also lead to the accumulation of metabolic waste products, which can cause damage to various organs.

Research has also suggested a link between variations in the SLC22A7 gene and the risk of developing certain diseases. For example, a study found that people with certain variations in this gene had a higher risk of developing gout.

See Also

• Solute carrier family
• Organic anion transporter
• Gout

References

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