SGCA
SGCA (Sarcoglycan Alpha) is a protein that in humans is encoded by the SGCA gene. It is a component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex (DGC) which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Function[edit]
The SGCA gene provides instructions for making a protein called alpha-sarcoglycan. This protein is found in muscle cells, where it plays a crucial role in maintaining the stability and integrity of these cells. Alpha-sarcoglycan is part of a group of proteins that work together to strengthen muscle fibers and prevent them from being damaged during muscle contraction and relaxation.
Clinical significance[edit]
Mutations in the SGCA gene cause Limb-girdle muscular dystrophy type 2D (LGMD2D), a form of muscular dystrophy characterized by progressive weakness and wasting of the muscles of the hip and shoulder girdles.
See also[edit]
References[edit]
<references />
External links[edit]
 | This medical article is a stub. You can help WikiMD by expanding the page. |
Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
