Rigosertib
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Rigosertib (ON-01910 sodium salt, with Estybon as trade name) is a synthetic benzyl styryl sulfone in development by Onconova Therapeutics.<ref>
Onconova Therapeutics(link). {{{website}}}.
Accessed 2019-04-26.
</ref> Riosertib is in phase III clinical trials for the treatment of chronic myelomonocytic leukemia.<ref>https://clinicaltrials.gov/ct2/show/NCT01928537</ref>
Its geometrical isomer (Z)-ON 01910·Na has less cytotoxicity on cancer cells.
Mechanism[edit]
Rigosertib is a microtubule-destabilizing agent.<ref>,
Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent, Molecular Cell, 2017, Vol. 68(Issue: 1), pp. 210–223.e6, DOI: 10.1016/j.molcel.2017.09.012, PMID: 28985505, PMC: 5640507, Full text,</ref>
References[edit]
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