Rev (HIV)

Rev (HIV) is a regulatory protein that is encoded by the rev gene of the Human Immunodeficiency Virus (HIV). It plays a crucial role in the virus's replication cycle and is essential for the production of new viral particles.

Function

The primary function of Rev is to transport unspliced and partially spliced HIV RNA from the nucleus to the cytoplasm of the host cell. This process is critical for the production of the structural proteins and enzymes necessary for the assembly of new viral particles.

Rev accomplishes this by binding to a specific sequence in the viral RNA known as the Rev Response Element (RRE). Once bound, Rev forms a multimeric complex that interacts with the host cell's export machinery to transport the RNA out of the nucleus.

Structure

Rev is a relatively small protein, consisting of approximately 116 amino acids. It has a highly basic domain that allows it to bind to RNA, and a leucine-rich nuclear export signal (NES) that interacts with the host cell's export machinery. The structure of Rev is critical for its function, as mutations in key areas can significantly impair its ability to bind to the RRE and transport viral RNA.

Clinical significance

Given its essential role in the HIV replication cycle, Rev has been the target of several therapeutic strategies aimed at inhibiting its function. These include small molecules that interfere with Rev's ability to bind to the RRE, and gene therapy approaches that aim to disrupt the Rev gene itself.

However, the development of Rev inhibitors has been challenging due to the protein's ability to rapidly mutate and develop resistance. Despite these challenges, research into Rev and its function continues to be a key area of focus in the ongoing fight against HIV.

See also

• HIV/AIDS
• Antiretroviral therapy
• HIV replication cycle

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Rev (HIV)

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  HIV-1 REV-RRE ribonucleoprotein complex

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  RRE mRNA IIB binding site

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  Specific contacts between ARM residues R39 and R35 and RRE mRNA nucleotides

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  Specific contacts between ARM residues R44 and N40 with RRE mRNA nucleotides