Retinoic acid syndrome
Retinoic Acid Syndrome
Retinoic Acid Syndrome (pronunciation: reh-tin-OH-ic AH-sid SIN-drome) is a potentially severe complication that can occur in patients undergoing treatment with retinoic acid, a form of vitamin A used in the treatment of acute promyelocytic leukemia (APL).
Etymology
The term "Retinoic Acid Syndrome" is derived from the name of the drug, retinoic acid, which can cause the syndrome, and the Greek word "syndrome", which means "running together" of symptoms.
Definition
Retinoic Acid Syndrome is characterized by fever, respiratory distress, pulmonary infiltrates, and pleural or pericardial effusions, with or without leukocytosis. It is typically associated with the use of all-trans retinoic acid (ATRA), a medication used to treat APL.
Symptoms
Symptoms of Retinoic Acid Syndrome may include:
- Fever
- Difficulty breathing
- Rapid weight gain
- Swelling in the lower legs or hands
- Unusual tiredness or weakness
Treatment
Treatment typically involves discontinuation of ATRA and administration of dexamethasone. In severe cases, hospitalization may be required.
Related Terms
- Acute Promyelocytic Leukemia
- All-trans Retinoic Acid (ATRA)
- Dexamethasone
- Leukocytosis
- Pericardial Effusion
- Pulmonary Infiltrates
- Vitamin A
External links
- Medical encyclopedia article on Retinoic acid syndrome
- Wikipedia's article - Retinoic acid syndrome
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