Replication error phenotype
Replication Error Phenotype
Replication error phenotype (pronunciation: /rɪˌplɪkeɪʃən ˈɛrər fiːnətaɪp/) is a term used in genetics to describe a condition where the DNA replication process is prone to errors, leading to an increased rate of mutations. The term is often associated with certain types of cancer, where a high mutation rate can drive the development and progression of the disease.
Etymology
The term "replication error phenotype" is derived from the process it describes. "Replication" refers to the process of duplicating DNA, "error" refers to the mistakes that can occur during this process, and "phenotype" refers to the observable characteristics that result from these errors.
Related Terms
- Microsatellite instability: A condition that is often associated with replication error phenotype, characterized by the accumulation of mutations in microsatellite regions of the DNA.
- Mismatch repair: A system for recognizing and repairing erroneous insertion, deletion, and mis-incorporation of bases that can arise during DNA replication and recombination, as well as repairing some forms of DNA damage.
- Mutator phenotype: A term used to describe cells that have an exceptionally high mutation rate, often due to defects in DNA repair mechanisms such as mismatch repair.
See Also
External links
- Medical encyclopedia article on Replication error phenotype
- Wikipedia's article - Replication error phenotype
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