Ramosetron

Ramosetron is a serotonin 5-HT3 receptor antagonist used in the treatment and prevention of nausea and vomiting following surgery or chemotherapy. It is also used for the treatment of irritable bowel syndrome.

Pharmacology

Ramosetron works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting. It is a highly selective 5-HT3 receptor antagonist with a strong binding affinity for this receptor.

Medical uses

Ramosetron is used for the prevention and treatment of postoperative nausea and vomiting. It is also used for the prevention of nausea and vomiting associated with cancer chemotherapy. In addition, it is used for the treatment of irritable bowel syndrome.

Side effects

Common side effects of ramosetron include constipation, headache, and dizziness. Less common side effects include abdominal pain, insomnia, and abnormal liver function tests.

Contraindications

Ramosetron is contraindicated in patients with known hypersensitivity to the drug or any of its components. It is also contraindicated in patients with severe liver disease.

Interactions

Ramosetron may interact with other drugs that affect serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs).

See also

• 5-HT3 antagonist
• Serotonin
• Nausea
• Vomiting
• Irritable bowel syndrome

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