RKI-1447

RKI-1447 is a small molecule inhibitor of Rho-associated protein kinase (ROCK), a serine/threonine-specific protein kinase that is involved in the regulation of the shape and movement of cells. RKI-1447 was developed by researchers at the Rutgers Cancer Institute of New Jersey and is currently being studied for its potential use in the treatment of cancer and other diseases.

Mechanism of Action

RKI-1447 works by inhibiting the activity of ROCK, which is involved in the formation of stress fibers and focal adhesions, structures that are important for cell movement. By inhibiting ROCK, RKI-1447 can prevent the formation of these structures and thus inhibit cell movement. This can be particularly useful in the treatment of cancer, as it can prevent cancer cells from spreading to other parts of the body, a process known as metastasis.

Potential Therapeutic Applications

The primary potential therapeutic application of RKI-1447 is in the treatment of cancer. In preclinical studies, RKI-1447 has been shown to inhibit the growth and spread of several types of cancer cells, including breast cancer cells, lung cancer cells, and melanoma cells. In addition to its potential use in cancer treatment, RKI-1447 may also have applications in the treatment of other diseases that involve abnormal cell movement, such as atherosclerosis and rheumatoid arthritis.

Clinical Trials

As of now, RKI-1447 is still in the preclinical stage of development, and has not yet been tested in humans. However, the results of preclinical studies have been promising, and it is hoped that clinical trials will be able to begin in the near future.

Safety and Side Effects

The safety and side effects of RKI-1447 are not yet known, as it has not yet been tested in humans. However, in preclinical studies, it has been shown to be well-tolerated in animals.

See Also

• Rho-associated protein kinase
• Cancer
• Metastasis
• Breast cancer
• Lung cancer
• Melanoma
• Atherosclerosis
• Rheumatoid arthritis

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  RKI-1447 Structure