RG7795
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| RG7795 | |
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| [[File:|frameless|220px|alt=|]] | |
| INN | |
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| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
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| Legal status | Investigational |
| CAS Number | 1174920-78-5 |
| PubChem | |
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RG7795 (previously ANA773) is an antiviral drug candidate that as of 2015 had been in Phase II trials in hepatitis B.[1] It is an orally-available prodrug of isatoribine,[2] that was under development by Anadys Pharmaceuticals when it was acquired by Roche in 2011.[3] Its active metabolite is an [agonist]] of TLR7; activation of TLR7 causes secretion of endogenous type 1 interferons, which have antiviral activity.[2]
References
- ↑ RG 7795(link). {{{website}}}. AdisInsight.
- ↑ 2.0 2.1 , Tickling the TLR7 to cure viral hepatitis., Journal of Translational Medicine, Vol. 12, pp. 129, DOI: 10.1186/1479-5876-12-129, PMID: 24884741, PMC: 4039542,
- ↑ , Inovio Goes It Alone on Hepatitis B Immunotherapy Vaccine as Roche Ends Collaboration Full text, Genetic Engineering News, August 3, 2016,
RG7795
RG-7795
Isatoribine
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Contributors: Prab R. Tumpati, MD
