RG7795

RG7795 ; ; ; ; ; ; ; ; ; ; ;
Legal status	Investigational
CAS Number	1174920-78-5 ; ; ; ; ; ;

RG7795 (previously ANA773) is an antiviral drug candidate that as of 2015 had been in Phase II trials in hepatitis B.^[1] It is an orally-available prodrug of isatoribine,^[2] that was under development by Anadys Pharmaceuticals when it was acquired by Roche in 2011.^[3] Its active metabolite is an [agonist]] of TLR7; activation of TLR7 causes secretion of endogenous type 1 interferons, which have antiviral activity.^[2]

References[edit]

↑ RG 7795(link). AdisInsight.
↑ ^2.0 ^2.1 "Tickling the TLR7 to cure viral hepatitis.".Journal of Translational Medicine.14 May 2014;12
129.doi:10.1186/1479-5876-12-129.PMID:24884741.PMC:4039542.
↑ , Inovio Goes It Alone on Hepatitis B Immunotherapy Vaccine as Roche Ends Collaboration Full text, Genetic Engineering News, August 3, 2016,

RG7795[edit]

RG-7795
Isatoribine

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[Adis-1] RG 7795(link). AdisInsight.

[Funk-2] 2.0 ^2.1 "Tickling the TLR7 to cure viral hepatitis.".Journal of Translational Medicine.14 May 2014;12
129.doi:10.1186/1479-5876-12-129.PMID:24884741.PMC:4039542.

[3] , Inovio Goes It Alone on Hepatitis B Immunotherapy Vaccine as Roche Ends Collaboration Full text, Genetic Engineering News, August 3, 2016,

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