RAMP3

RAMP3

Receptor activity modifying protein 3 (RAMP3) is a protein that in humans is encoded by the RAMP3 gene. RAMP3 is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs).

Function

RAMPs are type I transmembrane proteins that assist in the transport and function of receptors. In particular, RAMP3 is known to interact with the calcitonin receptor-like receptor (CLR) to modulate its function. This interaction can influence the receptor's ligand specificity, tissue distribution, and signal transduction.

Clinical Significance

RAMP3 has been implicated in various diseases and conditions. For instance, it has been associated with cancer, hypertension, and cardiovascular disease. In cancer, RAMP3 overexpression has been observed in several types of tumors, suggesting a potential role in tumor progression. In hypertension, RAMP3 may play a role in regulating blood pressure. In cardiovascular disease, RAMP3 may be involved in the regulation of vascular tone and heart rate.

Research

Research into RAMP3 is ongoing, with studies focusing on its role in disease progression and potential as a therapeutic target. For example, researchers are investigating the potential of RAMP3 inhibitors as a treatment for cancer and hypertension.

See Also

• RAMP1
• RAMP2
• Calcitonin receptor-like receptor
• G protein-coupled receptor

References

   This article is a protein-related stub. You can help WikiMD by expanding it!

   This article is a medical stub. You can help WikiMD by expanding it!