Pyrrolizidine alkaloidosis
Pyrrolizidine Alkaloidosis
Pyrrolizidine alkaloidosis (pronunciation: pir-ol-iz-i-deen al-ka-loid-o-sis) is a medical condition caused by the ingestion of plants containing pyrrolizidine alkaloids.
Etymology
The term "Pyrrolizidine alkaloidosis" is derived from the name of the group of naturally occurring alkaloids, "Pyrrolizidine", which are found in certain plants and are toxic to humans and animals when ingested. The suffix "-osis" is used in medical terminology to denote a disorder or disease condition.
Definition
Pyrrolizidine alkaloidosis is a disease condition characterized by liver damage and other health problems caused by the ingestion of plants containing pyrrolizidine alkaloids. These alkaloids are found in a wide variety of plants worldwide and are particularly toxic to the liver.
Symptoms
The symptoms of pyrrolizidine alkaloidosis can vary depending on the amount of alkaloids ingested and the duration of exposure. Common symptoms include loss of appetite, rapid weight loss, jaundice, ascites, and photosensitization. In severe cases, it can lead to liver failure and death.
Diagnosis
Diagnosis of pyrrolizidine alkaloidosis is often based on the patient's history of exposure to plants containing these alkaloids, clinical signs, and laboratory findings. Liver biopsy may also be performed to confirm the diagnosis.
Treatment
Treatment for pyrrolizidine alkaloidosis primarily involves removing the source of the alkaloids from the patient's diet and providing supportive care. In severe cases, liver transplantation may be necessary.
Related Terms
External links
- Medical encyclopedia article on Pyrrolizidine alkaloidosis
- Wikipedia's article - Pyrrolizidine alkaloidosis
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