Pyrimidine metabolism

Pyrimidine metabolism is a crucial process in the body that involves the synthesis and degradation of pyrimidines. Pyrimidines are one of the two types of nitrogenous bases found in nucleic acids, the other being purines. The most common pyrimidines are cytosine, thymine, and uracil.

Synthesis

The synthesis of pyrimidines is simpler than that of purines. The process begins with the formation of a simple ring structure by the enzyme aspartate transcarbamylase. This ring is then built upon with additional atoms to form a pyrimidine. The entire process is regulated by feedback inhibition, with the end product, CTP, inhibiting the first step in the pathway.

Degradation

The degradation of pyrimidines results in beta-amino acids, which can be further broken down into CO2, H2O, and NH3. Unlike purines, pyrimidines are not recycled in the body.

Disorders

Disorders of pyrimidine metabolism are rare but can be severe. They include orotic aciduria, a condition that can cause physical and mental retardation, and hereditary orotic aciduria, which can cause anemia and growth retardation.

Treatment

Treatment for disorders of pyrimidine metabolism typically involves dietary modifications and supplementation with the missing or deficient product. In some cases, bone marrow transplantation may be necessary.

See also

• Purine metabolism
• Nucleotide metabolism
• Metabolic pathway
• Metabolic disorder

References

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