Pseudohypertrophy

Pseudohypertrophy (/ˌsjuːdoʊhaɪˈpɜːrtrəfi/; from the Greek words pseudo meaning false, hyper meaning over, and trophy meaning nourishment) is a medical term used to describe an increase in the size of an organ or tissue that is not due to an increase in the number or size of cells, but rather due to an accumulation of substances within the cells or tissue.

Definition

Pseudohypertrophy is often associated with certain muscular dystrophies, particularly Duchenne muscular dystrophy. In these conditions, the muscle tissue is replaced by fat and connective tissue, giving the appearance of increased muscle mass. However, this is not true hypertrophy as the muscle fibers themselves are not enlarged.

Symptoms

The main symptom of pseudohypertrophy is the appearance of enlarged muscles. However, despite the increased size, the muscles are often weak and may not function properly. Other symptoms can vary depending on the underlying condition causing the pseudohypertrophy.

Causes

Pseudohypertrophy can be caused by a variety of conditions, including certain types of muscular dystrophy, lipodystrophy, and some metabolic disorders. It can also occur as a result of certain medications or treatments.

Diagnosis

Diagnosis of pseudohypertrophy typically involves a physical examination and medical history. Additional tests, such as a muscle biopsy, may be performed to confirm the diagnosis and identify the underlying cause.

Treatment

Treatment for pseudohypertrophy focuses on managing the underlying condition causing the pseudohypertrophy. This may involve medication, physical therapy, or other treatments as appropriate.

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Pseudohypertrophy