Protein c-Fos
Protein c-Fos
Protein c-Fos (/ˈproʊtiːn siː fɒs/) is a protein that in humans is encoded by the FOS gene. It is a member of the AP-1 transcription factor family. This protein has been found to be a critical component of the cellular response to various stimuli, including growth factors, inflammatory cytokines, and stress signals.
Etymology
The term "c-Fos" is derived from the name of the Finkel-Biskis-Jinkins murine osteosarcoma virus (FBJ-MuSV), which carries a gene that is a homolog of the human FOS gene. The "c" in c-Fos stands for "cellular," distinguishing it from the viral gene (v-Fos).
Function
Protein c-Fos functions as a nuclear transcription factor, which means it helps to regulate the expression of genes in the nucleus of a cell. It forms a complex with another protein, c-Jun, and this complex binds to specific regions of DNA to control the transcription of genes.
Related Terms
- AP-1 transcription factor: A transcription factor that c-Fos is a part of. It is involved in cellular responses to a wide array of stimuli.
- c-Jun: A protein that forms a complex with c-Fos to control gene transcription.
- Gene: A unit of heredity which is transferred from a parent to offspring and is held to determine some characteristic of the offspring.
- Protein: Large biomolecules and macromolecules that comprise one or more long chains of amino acid residues.
- Inflammatory cytokines: A type of signaling molecule that is secreted from immune cells and certain other cell types that promotes inflammation.
- Cellular response: The specific reactions and events that occur in a cell in response to a stimulus.
External links
- Medical encyclopedia article on Protein c-Fos
- Wikipedia's article - Protein c-Fos
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