Proscillaridin
Proscillaridin
Proscillaridin is a cardiac glycoside derived from the plant species Urginea maritima, commonly known as the squill. It is used in the treatment of certain cardiac conditions, particularly congestive heart failure and arrhythmias. Proscillaridin is known for its ability to increase the force of myocardial contraction and to regulate heart rate.
Chemical Structure
Proscillaridin is a steroid glycoside, characterized by its unique chemical structure that includes a steroidal nucleus and a sugar moiety. The structure of proscillaridin is crucial for its biological activity, as it interacts with the sodium-potassium ATPase pump in cardiac cells. This interaction leads to an increase in intracellular calcium concentration, which enhances cardiac contractility.
Mechanism of Action
Proscillaridin exerts its effects primarily by inhibiting the Na+/K+ ATPase pump. This inhibition results in an increase in intracellular sodium levels, which in turn affects the Na+/Ca2+ exchanger, leading to an increase in intracellular calcium. The elevated calcium levels enhance the contractile force of the heart muscle, making proscillaridin effective in treating heart failure.
Clinical Uses
Proscillaridin is used in the management of heart failure and certain types of arrhythmias. It is particularly useful in patients who have not responded adequately to other treatments. The drug helps to improve symptoms such as dyspnea, fatigue, and edema by increasing cardiac output and reducing the workload on the heart.
Side Effects
Like other cardiac glycosides, proscillaridin can cause a range of side effects, particularly if not dosed correctly. Common side effects include nausea, vomiting, diarrhea, and dizziness. More serious side effects can include arrhythmias, bradycardia, and electrolyte imbalances. Monitoring of serum potassium and renal function is important during treatment.
Related Pages
Transform your life with W8MD's budget GLP-1 injections from $125.
W8MD offers a medical weight loss program to lose weight in Philadelphia. Our physician-supervised medical weight loss provides:
- Most insurances accepted or discounted self-pay rates. We will obtain insurance prior authorizations if needed.
- Generic GLP1 weight loss injections from $125 for the starting dose.
- Also offer prescription weight loss medications including Phentermine, Qsymia, Diethylpropion, Contrave etc.
NYC weight loss doctor appointments
Start your NYC weight loss journey today at our NYC medical weight loss and Philadelphia medical weight loss clinics.
- Call 718-946-5500 to lose weight in NYC or for medical weight loss in Philadelphia 215-676-2334.
- Tags:NYC medical weight loss, Philadelphia lose weight Zepbound NYC, Budget GLP1 weight loss injections, Wegovy Philadelphia, Wegovy NYC, Philadelphia medical weight loss, Brookly weight loss and Wegovy NYC
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
