Proliferative index
Proliferative Index
The Proliferative Index (pronounced pro-lif-er-a-tive in-dex) is a term used in Pathology and Oncology to measure the growth rate of a tumor or cancer cell population. It is often used to predict the aggressiveness of the disease and to guide treatment decisions.
Etymology
The term "Proliferative Index" is derived from the Latin word "proles" meaning offspring and "ferre" meaning to bear. The term "index" is derived from the Latin word "indicis" meaning pointer or indicator. Thus, the term "Proliferative Index" can be interpreted as an indicator of offspring bearing, referring to the rate at which cells are dividing and producing new cells.
Usage
In medical practice, the Proliferative Index is often determined by using Immunohistochemistry to detect the presence of certain proteins that are only expressed during cell division. The most commonly used marker is Ki-67, but others such as PCNA and MCM are also used. The percentage of cells that are positive for these markers is then calculated to give the Proliferative Index.
A high Proliferative Index is generally associated with a more aggressive tumor and a poorer prognosis. However, it is not the only factor that is considered when making treatment decisions. Other factors such as the type and stage of the cancer, the patient's overall health, and the patient's personal preferences are also taken into account.
Related Terms
External links
- Medical encyclopedia article on Proliferative index
- Wikipedia's article - Proliferative index
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