Progressive transformation of germinal centres

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Progressive transformation of germinal centres
File:Progressive transformation of germinal centres -1- very low mag.jpg
Synonyms progressive transformation of germinal centers
Pronounce
Field Infectious disease
Symptoms
Complications
Onset
Duration
Types
Causes
Risks
Diagnosis
Differential diagnosis
Prevention
Treatment
Medication
Prognosis
Frequency
Deaths


Progressive transformation of germinal centres (PTGCs) is a reactive lymph node process of undetermined cause.

Signs and symptoms[edit]

PTGC is usually characterized by localized lymphadenopathy and is otherwise typically asymptomatic.

Diagnosis[edit]

File:Progressive transformation of germinal centres -1- low mag.jpg
Micrograph showing PTGCs. H&E stain.

PTGC is diagnosed by surgical excision of the affected lymph node(s), and examination by a pathologist. The differential diagnosis includes non-neoplastic causes of lymphadenopathy (e.g. cat-scratch fever, Kikuchi disease) and malignancy, i.e. cancer.

Microscopic appearance[edit]

PTGCs is characterized by:[1]

  • follicular hyperplasia (many follicles),
  • focally large germinal centres, with poorly demarcated germinal centre (GC)/mantle zone interfaces (as GCs infiltrated by mantle zone lymphocytes), and
  • an expanded mantle zone.

Treatment[edit]

PTGC is treated by excisional biopsy and follow-up. It may occasionally recur and in a small proportion of patients has been reported to subsequently develop Hodgkin lymphoma (usually nodular lymphocyte predominant Hodgkin lymphoma).[2][3]

See also[edit]

References[edit]

  1. ↑ "Progressive transformation of germinal centers. Report of 2 cases and review of the literature".Acta Haematol..2002;108(1)
    33–8.doi:10.1159/000063057.PMID:12145465.
  2. ↑ "Progressive transformation of germinal centers with and without association to Hodgkin's disease".Am. J. Clin. Pathol..February 1990;93(2)
    219–26.PMID:2405631.
  3. ↑ "Progressive transformation of germinal centers: a clinicopathological study of 42 Japanese patients".Int. J. Surg. Pathol..April 2003;11(2)
    101–7.doi:10.1177/106689690301100205.PMID:12754626.

External links[edit]

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