Pregnancy and lactation-associated osteoporosis

Pregnancy and lactation-associated osteoporosis
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Synonyms	Pregnancy-associated osteoporosis (PAO)
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Field	OB/GYN
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Pregnancy- and lactation-associated osteoporosis (PLO; also known as pregnancy-related osteoporosis) is a rare early presentation of osteoporosis in which young women experience low trauma or spontaneous fractures during or soon after pregnancy or lactation.

Fragility fractures of the spine are most commonly described, but the condition can be associated with other types of fracture. <ref>,

 Osteoporosis presenting in pregnancy, puerperium, and lactation., 
 Current Opinion in Endocrinology, Diabetes and Obesity, 
 2014,
 Vol. 21(Issue: 6),
 pp. 468–475,
 DOI: 10.1097/MED.0000000000000102,
 PMID: 25191853,
 
 
 Full text,</ref> <ref>, 
 Subsequent fracture risk of women with pregnancy and lactation associated osteoporosis after a median of 6 years of follow up., 
 Osteoporosis International, 
 2018,
 Vol. 29(Issue: 1),
 pp. 135–142,
 DOI: 10.1007/s00198-017-4239-1,
 PMID: 28965212,</ref>The symptoms usually appear during or after a first pregnancy with the most common complaint being severe back pain<ref>, 
 Pregnancy-associated osteoporosis., 
 Q J Med, 
 1995,
 Vol. 88,
 pp. 865–887,</ref> 

The exact causes of the disease are not yet known, and most women with PLO have no known predisposing cause of osteoporosis or bone fragility.<ref>,

 Pregnancy associated osteoporosis., 
 Clin Endocrinol, 
 1993,
 Vol. 39(Issue: 4),
 pp. 487–490,
 DOI: 10.1111/j.1365-2265.1993.tb02398.x,</ref>

References

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