Potter sequence
Potter Sequence
Potter Sequence (pronunciation: /ˈpɒtər ˈsiːkwəns/), also known as Potter Syndrome or Potter's Sequence, is a rare congenital condition characterized by a series of typical physical features that occur due to a lack of amniotic fluid in the womb. The term "Potter" is derived from the name of the American pathologist, Edith Potter, who first described the condition in 1946.
Etiology
The primary cause of Potter Sequence is a decrease in amniotic fluid, known as Oligohydramnios. This can occur due to a variety of reasons, including kidney abnormalities such as Renal Agenesis (absence of one or both kidneys), Polycystic Kidney Disease, or obstruction of the urinary tract.
Clinical Features
The typical physical features of Potter Sequence include Pulmonary Hypoplasia (underdeveloped lungs), characteristic facial features (Potter facies) such as wide-set eyes, low-set ears, and a broad, flat nose, as well as limb deformities. Other associated features may include Clubfoot and Hip Dysplasia.
Diagnosis and Treatment
Diagnosis of Potter Sequence is often made prenatally through ultrasound examination. Postnatal diagnosis is based on the characteristic physical features and confirmed by imaging studies. Treatment is supportive and depends on the severity of the condition and the associated anomalies.
Prognosis
The prognosis for Potter Sequence is generally poor, with many infants not surviving past the neonatal period due to severe lung underdevelopment. However, with advances in neonatal intensive care, some infants with milder forms of the condition may survive.
See Also
- Renal Agenesis
- Oligohydramnios
- Pulmonary Hypoplasia
- Polycystic Kidney Disease
- Clubfoot
- Hip Dysplasia
External links
- Medical encyclopedia article on Potter sequence
- Wikipedia's article - Potter sequence
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