Post-mortem chemistry

From WikiMD's medical encyclopedia

Post-mortem chemistry (also known as forensic toxicology or post-mortem toxicology) is a branch of forensic science that studies the chemical changes that occur in the body after death. This field is crucial in determining the cause and manner of death, especially in cases of suspected poisoning or drug overdose.

Overview

Post-mortem chemistry involves the analysis of various biological samples such as blood, urine, and tissues collected during an autopsy. The main goal is to identify and quantify any substances that may have contributed to the individual's death. This can include drugs, alcohol, poisons, and other toxic substances.

Techniques

Various analytical techniques are used in post-mortem chemistry. These include gas chromatography, liquid chromatography, mass spectrometry, and immunoassay. These techniques allow for the detection and quantification of a wide range of substances, even in small concentrations.

Challenges

One of the main challenges in post-mortem chemistry is the phenomenon of post-mortem redistribution. This refers to the movement of drugs or other substances from high concentration areas to low concentration areas within the body after death. This can significantly affect the interpretation of toxicology results.

Applications

Post-mortem chemistry is used in a variety of contexts, including criminal investigations, drug overdose cases, and in determining the cause of unexplained deaths. It can also provide valuable information in cases of sudden death due to heart disease or other medical conditions.

See also


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Contributors: Prab R. Tumpati, MD