Porokeratosis

Porokeratosis

Porokeratosis (/ˌpɔːrəʊˌkɛrəˈtoʊsɪs/) is a group of rare, chronic, genetic skin disorders characterized by the presence of disordered keratinization which results in the formation of annular plaques surrounded by a hyperkeratotic ridge.

Etymology

The term "porokeratosis" is derived from the Greek words "poros" meaning passage or pore, "kera" meaning horn, and "osis" meaning condition. It was first described by Mibelli in 1893.

Types

There are several types of porokeratosis, including:

• Porokeratosis of Mibelli
• Disseminated superficial actinic porokeratosis (DSAP)
• Porokeratosis palmaris et plantaris disseminata
• Linear porokeratosis
• Punctate porokeratosis

Each type is characterized by specific features and locations of the skin lesions.

Symptoms

Symptoms of porokeratosis may vary depending on the type, but generally include:

• Skin lesions that are brownish-red or skin-colored
• Lesions that have a thin, raised border
• Mild itching or burning in the affected area

Causes

Porokeratosis is believed to be caused by a genetic mutation, although the exact gene is not known. It is also associated with immunosuppression, exposure to sunlight, and radiation therapy.

Treatment

Treatment options for porokeratosis include:

• Topical treatments such as retinoids, 5-fluorouracil, and imiquimod
• Cryotherapy
• Laser therapy
• Dermabrasion

See also

• Keratinization
• Skin lesion
• Genetic disorder
• Immunosuppression

External links

• Medical encyclopedia article on Porokeratosis
• Wikipedia's article - Porokeratosis

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