Population stratification
Population Stratification
Population stratification (pronunciation: /pɒpjʊˈleɪʃən strætɪfɪˈkeɪʃən/) is a term used in Epidemiology and Genetic Studies to describe the situation where apparent differences are observed in the genetic structure of human populations.
Etymology
The term "population stratification" is derived from the words "population", which comes from the Latin word 'populus' meaning people, and "stratification", which originates from the Latin word 'stratum' meaning layer.
Definition
Population stratification refers to the differences in allele frequencies in a population due to systematic differences in ancestry rather than the effects of specific genes. It is a potential confounding factor in Genome-Wide Association Studies (GWAS) and can lead to false-positive results if not properly accounted for.
Related Terms
- Allele Frequency
- Ancestry
- Genome-Wide Association Studies (GWAS)
- Confounding Factor
- Genetic Structure
See Also
References
External links
- Medical encyclopedia article on Population stratification
- Wikipedia's article - Population stratification
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