Pleomorphism (cytology)

Pleomorphism (cytology)

Pleomorphism in cytology refers to the variability in size, shape, and arrangement of cells and/or their nuclei. This term is often used in the context of cancer cells, which frequently exhibit pleomorphism. The degree of pleomorphism can be an indicator of the aggressiveness of a tumor.

Overview

Pleomorphism is a common feature of malignant cells, including those found in carcinomas, sarcomas, and lymphomas. It is one of the criteria used by pathologists to determine the grade of a tumor, with more pleomorphic tumors generally being of a higher grade.

Mechanisms

The mechanisms underlying pleomorphism in cancer cells are not fully understood. However, it is thought to be related to genetic instability, which is a hallmark of cancer. Genetic instability can lead to changes in the size and shape of the nucleus, as well as the overall cell.

Clinical significance

The degree of pleomorphism can have clinical implications. For example, tumors with a high degree of pleomorphism are generally more aggressive and have a poorer prognosis. In addition, pleomorphism can be used to differentiate between different types of tumors. For example, adenocarcinomas are typically more pleomorphic than squamous cell carcinomas.

See also

• Anaplasia
• Dysplasia
• Neoplasia
• Carcinoma
• Sarcoma
• Lymphoma

References

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Pleomorphism (cytology)

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