Plasmodium cynomolgi

Plasmodium cynomolgi is a species of parasitic protozoa that belongs to the genus Plasmodium. It is one of the several species of Plasmodium that cause malaria in non-human primates, particularly in macaque monkeys. This article provides an overview of Plasmodium cynomolgi, including its life cycle, transmission, symptoms, and treatment.

Life Cycle

The life cycle of Plasmodium cynomolgi is similar to other species of Plasmodium. It involves two hosts: the mosquito vector and the primate host. The cycle begins when an infected female Anopheles mosquito bites a macaque monkey, injecting sporozoites into the bloodstream. These sporozoites then travel to the liver, where they invade hepatocytes and undergo asexual replication, forming thousands of merozoites.

After a period of asexual replication, the merozoites are released into the bloodstream, where they invade red blood cells. Inside the red blood cells, the merozoites undergo further replication, leading to the release of more merozoites and the destruction of the infected red blood cells. This cycle of invasion, replication, and release continues, causing periodic episodes of fever and other symptoms.

In addition to the asexual replication, Plasmodium cynomolgi can also undergo sexual reproduction within the mosquito vector. When a mosquito feeds on an infected macaque, it ingests the gametocytes, which are the sexual forms of the parasite. Inside the mosquito's gut, the gametocytes mature into male and female gametes, which then fuse to form zygotes. The zygotes develop into ookinetes, which penetrate the mosquito's gut wall and form oocysts. The oocysts release sporozoites, which migrate to the mosquito's salivary glands, ready to be transmitted to another host during a subsequent blood meal.

Transmission

Plasmodium cynomolgi is primarily transmitted through the bite of infected Anopheles mosquitoes. When an infected mosquito feeds on a macaque monkey, it injects sporozoites into the bloodstream, initiating the infection. The sporozoites then travel to the liver, where they undergo asexual replication and eventually infect red blood cells, leading to the onset of malaria symptoms.

It is important to note that Plasmodium cynomolgi is not known to infect humans naturally. However, it is often used as a model organism in malaria research due to its similarities to human malaria parasites, such as Plasmodium falciparum and Plasmodium vivax.

Symptoms

The symptoms of Plasmodium cynomolgi infection in macaque monkeys are similar to those seen in other malaria infections. The most common symptoms include fever, chills, headache, muscle aches, and fatigue. In severe cases, the infection can lead to complications such as anemia, organ damage, and even death.

Treatment

The treatment of Plasmodium cynomolgi infection in macaque monkeys typically involves the use of antimalarial drugs, such as chloroquine or artemisinin-based combination therapies. These drugs are effective in clearing the parasite from the bloodstream and preventing further complications.

It is worth mentioning that the treatment of Plasmodium cynomolgi infection in macaque monkeys is primarily focused on animal welfare and research purposes. As mentioned earlier, this species of Plasmodium does not naturally infect humans.

See Also

• Plasmodium
• Malaria
• Anopheles mosquito

References

• 

  Plasmodium cynomolgi liver stage

• 

  Plasmodium cynomolgi liver stage