Phosphocreatine

Phosphocreatine, also known as creatine phosphate (pronunciation: fos-fo-kree-a-teen), is a naturally occurring organic compound that facilitates the recycling of adenosine triphosphate (ATP), the energy currency of the cell, primarily in muscle and brain tissue.

Etymology

The term "Phosphocreatine" is derived from the Greek words "phospho-" meaning light, and "creatine," which is derived from "kreas," meaning flesh. This is due to the compound's role in energy metabolism in muscle tissue.

Function

Phosphocreatine serves as a reservoir for high-energy phosphate, which can be utilized by the body's tissues, particularly the muscle and brain, to rapidly replenish ATP. This is crucial during periods of high energy demand.

Synthesis and Degradation

Phosphocreatine is synthesized in the liver and transported to the muscle cells, where it is stored until needed. The synthesis involves the enzyme creatine kinase, which transfers a phosphate group from ATP to creatine. The degradation of phosphocreatine, releasing creatine and phosphate, is also catalyzed by creatine kinase.

Clinical Significance

Abnormal phosphocreatine levels can indicate certain medical conditions. Low levels can suggest a problem with muscle metabolism, while high levels can indicate a condition that reduces the body's ability to use phosphocreatine.

Related Terms

External links

Medical encyclopedia article on Phosphocreatine
Wikipedia's article - Phosphocreatine

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Phosphocreatine