Phenmetrazine

Phenmetrazine is a stimulant drug that was previously used as an appetite suppressant, but has since been withdrawn from the market. It was initially marketed in the 1950s. Phenmetrazine was a problem drug, and is now a controlled substance in many countries due to its potential for addiction.

History

Phenmetrazine was first patented in Germany in 1952 by Boehringer-Ingelheim, with some pharmacological data appearing in the literature in 1954. It was the result of a search by the company for an anorectic drug to replace amphetamine, which was increasingly subject to abuse.

Pharmacology

Phenmetrazine acts as a norepinephrine-dopamine releasing agent (NDRA). It is also a metabolite of phendimetrazine, a more complex drug. Phenmetrazine stimulates the brain, increases heart rate, blood pressure and decreases appetite. Its effects can last from 3 to 4 hours.

Side Effects

Side effects of phenmetrazine include insomnia, hyperactivity, and restlessness. It can also cause palpitations, sweating, and dizziness. In severe cases, it can lead to psychosis.

Legal Status

Phenmetrazine is a controlled substance in many countries due to its potential for addiction. It is a Schedule II controlled substance in the United States.

See Also

• Amphetamine
• Phendimetrazine
• Stimulant
• Appetite suppressant

References

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Phenmetrazine

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  Structure of Phenmetrazine
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  Synthesis of Phenmetrazine