Perisinusoidal space

The Perisinusoidal space (pronunciation: per-i-si-nu-soi-dal space), also known as the Space of Disse, is a small area in the liver between a hepatocyte and a sinusoid. This space plays a crucial role in the exchange of materials between the hepatocytes and the blood in the sinusoids.

Etymology

The term "Perisinusoidal" is derived from the Latin words "peri" meaning around, and "sinusoidal" referring to the sinusoids in the liver. The space is named after the German anatomist, Joseph Disse, who first described it.

Function

The Perisinusoidal space is filled with a rich network of collagen fibers and stellate cells. It serves as a pathway for the transport of various substances, including oxygen, nutrients, and waste products, between the blood in the sinusoids and the hepatocytes.

Related Terms

Hepatocyte: The main cell type in the liver, responsible for protein synthesis, detoxification, and metabolism.
Sinusoid: A small, blood vessel found in the liver, spleen, and bone marrow.
Stellate cell: A type of cell found in the perisinusoidal space that plays a role in liver fibrosis.
Collagen: The main structural protein in the extracellular space in various connective tissues.

External links

Medical encyclopedia article on Perisinusoidal space
Wikipedia's article - Perisinusoidal space

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Perisinusoidal space