Pentosan

Pentosan is a medication that is primarily used in the treatment of osteoarthritis. It is classified as a disease-modifying osteoarthritis drug (DMOAD), and it works by improving the health of the joint cartilage. Pentosan is also used in veterinary medicine, particularly for the treatment of osteoarthritis in dogs and horses.

Pharmacology

Pentosan is a semi-synthetic drug manufactured from beechwood hemicelluloses. It has both anticoagulant and fibrinolytic properties, but its primary mechanism of action in treating osteoarthritis is not fully understood. It is believed to stimulate the synthesis of proteoglycans, which are essential components of the joint cartilage.

Uses

Pentosan is used in the treatment of osteoarthritis in humans, dogs, and horses. It is administered via injection, and the typical course of treatment involves multiple injections over several weeks. In addition to its use in treating osteoarthritis, pentosan has also been investigated for potential use in treating interstitial cystitis and thrombosis.

Side Effects

Like all medications, pentosan can cause side effects. The most common side effects include gastrointestinal upset, skin reactions at the injection site, and changes in liver function. In rare cases, pentosan can cause serious side effects such as bleeding complications and liver toxicity.

See Also

• Osteoarthritis
• Disease-modifying osteoarthritis drugs
• Proteoglycans

References

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