Papuloerythroderma of Ofuji

Papuloerythroderma of Ofuji
Synonyms	Ofuji's disease
Pronounce	N/A
Specialty	Dermatology
Symptoms	Pruritus, erythroderma, papules
Complications	N/A
Onset	Typically in adulthood
Duration	Chronic
Types	N/A
Causes	Unknown, possibly immune system related
Risks	Male gender, elderly age
Diagnosis	Clinical diagnosis, skin biopsy
Differential diagnosis	Psoriasis, eczema, drug eruption
Prevention	N/A
Treatment	Systemic corticosteroids, phototherapy, immunosuppressive therapy
Medication	N/A
Prognosis	Variable, can be chronic and relapsing
Frequency	Rare
Deaths	N/A

Papuloerythroderma of Ofuji is a rare skin condition first described by Japanese dermatologists Ofuji et al. in 1984. It is characterized by the presence of red, flat, and slightly elevated papules that tend to coalesce into large plaques. The disease is more common in elderly individuals and has been associated with various internal malignancies.

Clinical Features

The primary clinical feature of Papuloerythroderma of Ofuji is the presence of red, flat, and slightly elevated papules. These papules often coalesce to form large plaques that cover a significant portion of the body. The plaques are typically symmetrical and have a characteristic "deck-chair" distribution, sparing the skin folds. Other symptoms may include pruritus, fever, and malaise.

Pathogenesis

The exact cause of Papuloerythroderma of Ofuji is unknown. However, it is believed to be a reactive process triggered by various factors such as drugs, infections, and malignancies. The disease has been associated with various internal malignancies, including lymphoma and gastric cancer.

Diagnosis

Diagnosis of Papuloerythroderma of Ofuji is primarily based on clinical features. Skin biopsy may be performed to rule out other conditions. Laboratory tests may be conducted to identify any underlying malignancies.

Treatment

Treatment of Papuloerythroderma of Ofuji primarily involves managing the symptoms and treating any underlying conditions. Topical corticosteroids and systemic therapies such as cyclosporine and methotrexate may be used.

Prognosis

The prognosis of Papuloerythroderma of Ofuji is generally good, especially when the underlying condition is treated. However, the disease tends to recur and may require long-term management.

See Also

• Dermatology
• Skin conditions
• Rare diseases

References

• Ofuji S, Furukawa F, Miyachi Y, Ohnishi Y, Hamada T, Hashimoto I. Papuloerythroderma. Dermatologica. 1984;169(3):125-30.
• Taniguchi S, Hamada T, Hashimoto I, Furukawa F, Ofuji S. Papuloerythroderma associated with gastric cancer. Dermatologica. 1986;172(4):209-13.
• Miyachi Y, Niwa Y. Papuloerythroderma. Dermatologica. 1987;175(5):242-7.

External Links

• Papuloerythroderma of Ofuji at DermNet NZ
• Papuloerythroderma of Ofuji at Orphanet