Oxprenoic acid
A synthetic steroid with antiandrogen properties
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Oxprenoic acid is a synthetic steroid with antiandrogen properties. It is primarily used in the treatment of conditions related to androgen excess.
Chemical structure
Oxprenoic acid is a derivative of progesterone, featuring a cyclopentanone ring attached to a butanoic acid moiety. This structure is responsible for its biological activity as an antiandrogen.
Mechanism of action
Oxprenoic acid functions by inhibiting the action of androgens, which are male sex hormones such as testosterone. It competes with androgens for binding to the androgen receptor, thereby reducing the effects of these hormones in the body.
Clinical uses
Oxprenoic acid is used in the management of conditions such as hirsutism, acne, and androgenic alopecia, which are often caused by excessive androgen activity. It may also be used in the treatment of polycystic ovary syndrome (PCOS), where androgen excess is a common feature.
Pharmacokinetics
The pharmacokinetic profile of oxprenoic acid includes its absorption, distribution, metabolism, and excretion. It is typically administered orally and undergoes hepatic metabolism. The metabolites are excreted primarily via the kidneys.
Side effects
Common side effects of oxprenoic acid include nausea, headache, and dizziness. As with other antiandrogens, it may also cause gynecomastia in males due to its effects on hormone balance.
Related compounds
Oxprenoic acid is related to other antiandrogens such as spironolactone and cyproterone acetate. These compounds share similar mechanisms of action and are used in the treatment of similar conditions.
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