Opioid epidemic in the United States

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Overview of the opioid epidemic in the United States


The opioid epidemic in the United States refers to the rapid increase in the use of prescription and non-prescription opioid drugs in the United States, beginning in the late 1990s and continuing into the present. This public health crisis has led to significant increases in opioid addiction, overdose deaths, and social and economic impacts.

Background

Opioids are a class of drugs that include the illegal drug heroin, synthetic opioids such as fentanyl, and prescription pain relievers such as oxycodone, hydrocodone, codeine, morphine, and others. These drugs are chemically related and interact with opioid receptors on nerve cells in the body and brain.

The opioid epidemic began in the late 1990s when pharmaceutical companies reassured the medical community that patients would not become addicted to prescription opioid pain relievers, leading healthcare providers to prescribe them at greater rates. This subsequently led to widespread misuse of these medications before it became clear that they could indeed be highly addictive.

Three Waves of the Epidemic

Three waves of opioid overdose deaths in the US

The opioid epidemic in the United States can be divided into three distinct waves:

First Wave

The first wave began in the 1990s with the increased prescribing of opioids, leading to a rise in overdose deaths involving prescription opioids. This wave was characterized by the misuse of prescription opioids such as oxycodone and hydrocodone.

Second Wave

The second wave began in 2010, marked by a rapid increase in overdose deaths involving heroin. As prescription opioids became more difficult to obtain, many individuals turned to heroin as a cheaper and more accessible alternative.

Third Wave

The third wave began in 2013, with significant increases in overdose deaths involving synthetic opioids, particularly illicitly manufactured fentanyl. This wave has been driven by the proliferation of fentanyl and its analogs, which are often mixed with heroin or cocaine, with or without the user's knowledge.

Impact on Public Health

Opioid deaths in the US

The opioid epidemic has had a profound impact on public health in the United States. Overdose deaths have increased dramatically, with opioids being involved in the majority of drug overdose deaths. The epidemic has also led to increases in HIV and hepatitis C infections due to needle sharing among people who inject drugs.

Economic Impact

The economic impact of the opioid epidemic is substantial, with costs related to healthcare, lost productivity, addiction treatment, and criminal justice involvement. The epidemic has strained healthcare systems and has had a significant impact on the workforce, with many individuals unable to work due to addiction or related health issues.

Efforts to Combat the Epidemic

Efforts to combat the opioid epidemic have included increasing access to addiction treatment services, expanding the availability of naloxone (a medication that can reverse an opioid overdose), and implementing prescription drug monitoring programs to reduce the over-prescribing of opioids.

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Contributors: Prab R. Tumpati, MD