Open reading frame
Open Reading Frame (ORF)
Open Reading Frame (ORF) (pronunciation: /ˈoʊpən ˈriːdɪŋ freɪm/) is a continuous stretch of codons in a DNA or RNA sequence that does not contain a stop codon. These frames are a fundamental concept in genomics and molecular biology, as they are the part of the genome that can potentially be translated into a protein.
Etymology
The term "Open Reading Frame" comes from the "open" nature of the sequence, meaning it is free of stop codons, and "reading frame," which refers to the way the sequence is read in sets of three nucleotides, or codons.
Related Terms
- Codon: A sequence of three DNA or RNA nucleotides that corresponds with a specific amino acid or stop signal during protein synthesis.
- Genome: The complete set of genes or genetic material present in a cell or organism.
- Molecular Biology: The branch of biology that deals with the structure and function of the macromolecules essential to life.
- Genomics: The study of genomes, including the sequencing, mapping, and analysis of an organism's entire genetic information.
See Also
- Gene: A unit of heredity which is transferred from a parent to offspring and is held to determine some characteristic of the offspring.
- Protein Synthesis: The process by which the genetic code puts together proteins in the cell.
- Translation (biology): The process by which a protein is synthesized from the genetic information carried by an mRNA molecule.
External links
- Medical encyclopedia article on Open reading frame
- Wikipedia's article - Open reading frame
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