OR10T2

OR10T2 is a gene that encodes a protein in the olfactory receptor family. This family is responsible for the detection of odorants in the nose and is the largest gene family in the mammalian genome. The OR10T2 gene is specifically involved in the detection of certain odorants, including those found in mint, citrus, and other aromatic compounds.

Structure

The OR10T2 gene is located on chromosome 1 in humans. It is composed of a single exon and encodes a protein that is 312 amino acids in length. The protein encoded by OR10T2 is a member of the G protein-coupled receptor family, which is characterized by seven transmembrane domains. These domains allow the protein to span the cell membrane and interact with odorant molecules in the environment.

Function

The OR10T2 protein is expressed in the olfactory epithelium, a specialized tissue in the nose that is responsible for detecting odorants. When an odorant molecule binds to the OR10T2 protein, it triggers a signal transduction pathway that ultimately leads to the perception of smell. The specific odorants that OR10T2 is sensitive to include mint, citrus, and other aromatic compounds.

Clinical significance

Mutations in the OR10T2 gene can lead to a reduced ability to smell, a condition known as anosmia. This can be caused by a variety of factors, including genetic mutations, damage to the olfactory epithelium, or neurological disorders. In some cases, anosmia can be a symptom of a more serious underlying condition, such as Parkinson's disease or Alzheimer's disease.

See also

• Olfactory receptor
• Anosmia
• G protein-coupled receptor

References

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