O6-Benzylguanine
O6-Benzylguanine
O6-Benzylguanine (pronounced oh-six-ben-zil-gwa-neen) is a synthetic derivative of guanine, one of the four main nucleobases found in the nucleic acids DNA and RNA. It is used as a biochemical tool in the study of DNA repair mechanisms and has potential therapeutic applications in the treatment of cancer.
Etymology
The term "O6-Benzylguanine" is derived from its chemical structure. The "O6" refers to the position of the oxygen atom in the guanine molecule, while "benzyl" refers to the benzyl group that is attached to the guanine base.
Related Terms
- Guanine: One of the four main nucleobases found in the nucleic acids DNA and RNA.
- DNA repair: The collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome.
- Cancer: A group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.
Usage
O6-Benzylguanine is a potent inhibitor of the DNA repair enzyme O6-alkylguanine-DNA alkyltransferase (AGT). By inhibiting this enzyme, O6-Benzylguanine can increase the effectiveness of certain chemotherapeutic agents, such as temozolomide, that cause damage to DNA.
See Also
External links
- Medical encyclopedia article on O6-Benzylguanine
- Wikipedia's article - O6-Benzylguanine
This WikiMD article is a stub. You can help make it a full article.
Languages: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski