O-Desmethylangolensin

desmethylangolensin.svg

O-Desmethylangolensin (O-DMA) is a metabolite of the isoflavone daidzein, which is found in various legumes, particularly soybeans. It is produced by the action of intestinal bacteria on daidzein and is considered to have various biological activities.

Biochemistry

O-Desmethylangolensin is formed in the human gut through the microbial metabolism of daidzein. The process involves the removal of a methyl group from daidzein, resulting in the formation of O-DMA. This compound is one of several metabolites of daidzein, others include equol and dihydrodaidzein.

Biological Activity

O-Desmethylangolensin has been studied for its potential estrogenic and anti-estrogenic activities. It can bind to estrogen receptors and may influence various physiological processes. The biological effects of O-DMA can vary depending on the individual's gut microbiota composition, which affects the production and metabolism of this compound.

Health Implications

The presence of O-Desmethylangolensin in the body has been associated with various health outcomes. Some studies suggest that it may have protective effects against certain hormone-dependent cancers, such as breast cancer and prostate cancer. However, the exact role of O-DMA in health and disease is still under investigation.

Research

Research on O-Desmethylangolensin is ongoing to better understand its role in human health. Studies are exploring its potential benefits and risks, as well as the factors that influence its production in the gut.

See Also

• Isoflavone
• Daidzein
• Equol
• Gut microbiota
• Estrogen receptor

References

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