Nikethamide

Nikethamide is a stimulant that primarily affects the respiratory system. It is also known as Coramine and Nicotinyl alcohol diacetate.

History

Nikethamide was first synthesized in the late 19th century. It was initially used as a treatment for drug overdose and respiratory failure. However, its use has declined due to the development of safer and more effective treatments.

Pharmacology

Nikethamide is a nicotinic acid derivative. It works by stimulating the central nervous system, specifically the medulla oblongata, which controls breathing. This stimulation increases the depth and rate of respiration, improving oxygenation of the blood.

Medical Uses

Nikethamide is used in emergency medicine to stimulate respiration in cases of drug overdose, respiratory failure, and COPD. It is also used in some countries as a performance-enhancing drug in sports, although it is banned by the World Anti-Doping Agency.

Side Effects

Common side effects of Nikethamide include nausea, vomiting, headache, and tachycardia. In rare cases, it can cause seizures or cardiac arrest.

Legal Status

Nikethamide is a prescription drug in many countries. It is also included in the World Anti-Doping Agency's list of prohibited substances, making its use in sports illegal.

See Also

• Stimulant
• Respiratory system
• Drug overdose
• Respiratory failure
• COPD
• World Anti-Doping Agency

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  Chemical structure of Nikethamide
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  Ball-and-stick model of the Nikethamide molecule
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