Nitroxoline

An article about the antibiotic Nitroxoline

Nitroxoline
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Nitroxoline is an antibiotic used primarily in the treatment of urinary tract infections (UTIs). It is a synthetic compound belonging to the class of 8-hydroxyquinoline derivatives. Nitroxoline is known for its broad-spectrum antimicrobial activity, particularly against Gram-positive and Gram-negative bacteria.

Mechanism of Action

Nitroxoline exerts its antibacterial effects by chelating metal ions that are essential for bacterial growth and metabolism. This chelation disrupts the function of bacterial enzymes, leading to inhibition of DNA synthesis and ultimately bacterial cell death. The drug is particularly effective against Escherichia coli, a common causative agent of UTIs.

Pharmacokinetics

After oral administration, nitroxoline is rapidly absorbed from the gastrointestinal tract. It is metabolized in the liver and excreted primarily in the urine, where it achieves high concentrations, making it particularly effective for treating urinary tract infections. The drug's half-life allows for dosing multiple times a day to maintain therapeutic levels.

Clinical Uses

Nitroxoline is primarily indicated for the treatment of uncomplicated urinary tract infections. It is also used in some cases for prophylaxis in patients undergoing urological procedures. Its use is limited in some regions due to the availability of newer antibiotics with broader spectra of activity.

Side Effects

Common side effects of nitroxoline include gastrointestinal disturbances such as nausea and vomiting. Some patients may experience allergic reactions, including skin rashes. Rarely, nitroxoline can cause peripheral neuropathy or optic neuritis, particularly with prolonged use.

Contraindications

Nitroxoline is contraindicated in patients with known hypersensitivity to 8-hydroxyquinolines. It should be used with caution in patients with severe liver or kidney impairment, as these conditions can affect the drug's metabolism and excretion.

Related pages

• Antibiotic
• Urinary tract infection
• Escherichia coli
• 8-hydroxyquinoline

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  Nitroxoline