Next generation sequencing

Next Generation Sequencing

Next Generation Sequencing (NGS), also known as high-throughput sequencing, is a term used to describe modern sequencing technologies that allow for the sequencing of DNA and RNA much more quickly and cheaply than the previously used Sanger sequencing, and as such has revolutionized the study of genomics and molecular biology.

Pronunciation

Next Generation Sequencing: /nɛkst ˈdʒɛnəˌreɪʃən ˈsiːkwənsɪŋ/

Etymology

The term "Next Generation Sequencing" is derived from the fact that these technologies are a step up from the "first generation" or traditional sequencing technologies, such as Sanger sequencing.

Related Terms

Overview

Next Generation Sequencing (NGS) is a method that has been developed to sequence DNA and RNA more quickly and cheaply than was previously possible. This has revolutionized the study of genomics and molecular biology by allowing researchers to study biological systems at a level that was not possible before.

NGS technologies can sequence DNA and RNA much more quickly and cheaply than the previously used Sanger sequencing. This has led to a massive increase in the amount of genomic data available.

Applications

NGS has a wide range of applications in medical and biological research, including in cancer genomics, genetic disease research, epigenetics, metagenomics, forensics, and agriculture.

Techniques

There are several techniques used in NGS, including whole genome sequencing, targeted sequencing, RNA sequencing, ChIP sequencing, and methyl sequencing.

Challenges

Despite its many advantages, NGS also presents some challenges, including data storage, data analysis, and the interpretation of results.

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Next generation sequencing