Neuropeptide Y receptor Y5

Neuropeptide Y receptor Y5 (also known as NPY5R) is a protein that in humans is encoded by the NPY5R gene. It is a G protein-coupled receptor that binds neuropeptide Y and peptide YY.

Function

The NPY5R is a receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. It is involved in various biological processes including food intake, anxiety, circadian rhythm, and neuroendocrine secretion.

Gene

The NPY5R gene is located on the long arm of chromosome 4 (4q31.3-q32). It spans approximately 5.3 kilobases and consists of two exons. The gene is expressed in various tissues, including the brain, spleen, small intestine, and colon.

Clinical significance

Alterations in the NPY5R gene have been associated with obesity and eating disorders. In addition, the receptor has been implicated in the regulation of bone mass and energy homeostasis.

See also

• Neuropeptide Y receptor
• Neuropeptide Y
• Peptide YY
• G protein-coupled receptor
• Adenylate cyclase

External links

• NPY5R at HUGO Gene Nomenclature Committee
• NPY5R at NCBI Gene

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