Nesfatin-1

Nesfatin-1 (pronounced: nes-fa-tin-one) is a protein that is encoded by the NUCB2 (nucleobindin 2) gene in humans. It is known for its role in the regulation of appetite and energy homeostasis.

Etymology

The term "Nesfatin" is derived from NEFA (non-esterified fatty acids) and "satiety". The "-1" denotes that it is the first of its kind to be discovered.

Function

Nesfatin-1 is an anorexigenic protein, meaning it suppresses appetite and contributes to the feeling of satiety. It is produced in various parts of the body, including the hypothalamus, the stomach, and the pancreas. In the hypothalamus, it is involved in the regulation of food intake and energy balance. In the stomach, it is thought to play a role in the regulation of gastric secretion and gastric motility. In the pancreas, it may be involved in the regulation of insulin secretion.

Clinical significance

Alterations in the levels of Nesfatin-1 have been associated with various medical conditions, including obesity, anorexia nervosa, and type 2 diabetes. It is thought that Nesfatin-1 could potentially be used as a therapeutic target for these conditions.

Related terms

• NUCB2
• Protein
• Appetite
• Energy homeostasis
• Anorexigenic
• Satiety
• Hypothalamus
• Stomach
• Pancreas
• Gastric secretion
• Gastric motility
• Insulin
• Obesity
• Anorexia nervosa
• Type 2 diabetes

External links

• Medical encyclopedia article on Nesfatin-1
• Wikipedia's article - Nesfatin-1

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