Narasin
Narasin is a polyether ionophore antibiotic used primarily in veterinary medicine as a coccidiostat and growth promoter. It is produced by the fermentation of the bacterium Streptomyces aureofaciens. Narasin is commonly used in the poultry and livestock industries to prevent and control coccidiosis, a parasitic disease affecting the intestinal tracts of animals.
Mechanism of Action
Narasin works by disrupting the ion transport across the cell membranes of coccidia parasites. It forms complexes with monovalent and divalent cations, such as sodium (Na+) and potassium (K+), facilitating their transport across the cell membrane. This disrupts the osmotic balance within the parasite, leading to its death.
Uses in Veterinary Medicine
Narasin is primarily used in the following ways:
- As a coccidiostat in poultry feed to prevent and control coccidiosis.
- As a growth promoter in livestock to improve feed efficiency and weight gain.
Safety and Regulation
Narasin is approved for use in many countries under strict regulations to ensure the safety of the food supply. It is important to follow the recommended dosages and withdrawal periods to prevent antibiotic residues in meat products.
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Narasin
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Contributors: Prab R. Tumpati, MD