Midkine
Midkine (also known as MK, NEGF2, or MDK) is a protein that in humans is encoded by the MDK gene. Midkine is a heparin-binding growth factor that is expressed in various cell types during embryogenesis. It promotes angiogenesis, cell growth, and cell migration.
Function[edit]
Midkine is a retinoic acid-responsive, heparin-binding growth factor that is expressed in various cell types during embryogenesis. It promotes angiogenesis, cell growth, and cell migration. Midkine is also expressed in several carcinoma cell lines, suggesting that it may play a role in tumor genesis, perhaps through its effects on angiogenesis.
Clinical significance[edit]
Midkine is overexpressed in many cancers, including ovarian cancer, neuroblastoma, and Wilms' tumor. It is also overexpressed in inflammatory diseases such as rheumatoid arthritis and atherosclerosis. Because of its overexpression in these diseases, midkine is a potential target for drug therapy.
See also[edit]
References[edit]
<references />
External links[edit]
 | This medical article is a stub. You can help WikiMD by expanding the page. |
Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
