Mesonephros
Mesonephros is an embryonic excretory organ that is part of the development of the urinary and reproductive organs. It is one of three excretory organs that develop in vertebrates, preceded by the pronephros and followed by the metanephros.
Development
The mesonephros develops from the intermediate mesoderm in the developing embryo. The intermediate mesoderm differentiates into a series of tubules known as mesonephric tubules. These tubules connect to the mesonephric duct, which will eventually form the reproductive tract in males. In females, the mesonephros degenerates and only vestigial structures remain.
Function
The mesonephros serves as the main excretory organ during the embryonic period of development. It filters waste products from the blood and excretes them into the amniotic fluid. The mesonephros also plays a role in the development of the reproductive system, particularly in males.
Clinical significance
Abnormal development of the mesonephros can lead to a number of medical conditions. These include renal agenesis, where one or both kidneys fail to develop, and renal dysplasia, where the kidneys do not develop properly. In addition, remnants of the mesonephros can give rise to mesonephric duct cysts or tumors.
See also
References
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Contributors: Prab R. Tumpati, MD
