Meropenem/vaborbactam

Meropenem/vaborbactam is a combination antibiotic used to treat complicated urinary tract infections (cUTI), including kidney infections. It contains meropenem, a carbapenem antibiotic, and vaborbactam, a beta-lactamase inhibitor. This combination is used to treat infections caused by certain bacteria that are resistant to meropenem alone.

Mechanism of Action

Meropenem works by inhibiting the formation of the bacterial cell wall, leading to cell death. Vaborbactam protects meropenem from degradation by certain enzymes (beta-lactamases) produced by bacteria, thereby enhancing the effectiveness of meropenem.

Uses

Meropenem/vaborbactam is used to treat complicated urinary tract infections, including pyelonephritis, caused by susceptible bacteria. It is also used to treat certain types of Klebsiella pneumoniae infections.

Side Effects

Common side effects of meropenem/vaborbactam include headache, diarrhea, and infusion site reactions. Serious side effects may include allergic reactions, seizures, and Clostridium difficile-associated diarrhea.

Drug Interactions

Meropenem/vaborbactam may interact with other medications, including valproic acid and probenecid.

Dosage and Administration

Meropenem/vaborbactam is administered intravenously. The dosage and duration of treatment depend on the type and severity of the infection.

Precautions

Before using meropenem/vaborbactam, patients should inform their healthcare provider if they have a history of allergies to beta-lactam antibiotics, kidney disease, or seizures.

See Also

• Antibiotics
• Urinary tract infection
• Kidney infection
• Klebsiella pneumoniae