MCM6

Ideogram human chromosome 2

MCM6

MCM6, also known as Minichromosome Maintenance Complex Component 6, is a gene that encodes a protein involved in DNA replication. It is part of the minichromosome maintenance (MCM) complex, which plays a crucial role in ensuring accurate DNA replication during cell division.

Function

The MCM6 protein is essential for the initiation of DNA replication. It acts as a helicase, unwinding the DNA double helix to allow for the synthesis of new DNA strands. This process is vital for the accurate duplication of genetic material and the transmission of genetic information to daughter cells.

Role in Cancer

Mutations in the MCM6 gene have been associated with various types of cancer. Dysregulation of DNA replication can lead to genomic instability and the development of cancerous cells. Studies have shown that aberrant expression of MCM6 is linked to tumor progression and poor prognosis in certain cancers.

Clinical Significance

The expression levels of MCM6 have been proposed as a potential biomarker for cancer diagnosis and prognosis. Targeting MCM6 and other components of the MCM complex may offer new therapeutic strategies for cancer treatment.

References

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