Losigamone
Losigamone
Losigamone (pronunciation: loh-si-ga-mo-ne) is a pharmacological agent that is primarily used as an antiepileptic drug (AED). It is known for its unique mechanism of action, which involves the modulation of gamma-aminobutyric acid (GABA) receptors in the brain.
Etymology
The term "Losigamone" is derived from its chemical structure, which is a derivative of the compound gamma-aminobutyric acid (GABA). The prefix "Losi-" is a modification of "lose", referring to the loss of a hydrogen atom in the chemical structure, and "-gamone" is derived from "gamma", referring to the gamma-aminobutyric acid structure.
Mechanism of Action
Losigamone works by enhancing the inhibitory effects of GABA in the brain. This is achieved by increasing the opening frequency of GABA_A receptor chloride channels, which leads to an increase in chloride ion influx and subsequent hyperpolarization of the neuron. This hyperpolarization makes the neurons less likely to fire, thereby reducing the likelihood of a seizure.
Related Terms
- Antiepileptic drug (AED): A type of medication used to prevent seizures in people with epilepsy.
- Gamma-aminobutyric acid (GABA): A neurotransmitter in the brain that inhibits the activity of neurons.
- GABA_A receptor: A type of receptor in the brain that responds to GABA.
See Also
External links
- Medical encyclopedia article on Losigamone
- Wikipedia's article - Losigamone
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